David Weiner, MD

David Weiner, MD
Co-holder, C. Craig and Audrae Tisher Chair in Nephrology 
Professor of Medicine and Physiology and Functional Genomics 
Division of Nephrology, Hypertension & Renal Transplantation
Chief, Nephrology and Hypertension Section, NF/SGVHS

1600 SW Archer Road
Room VA A531, VA Building
PO Box 100224
Gainesville, FL 32610-0277

TEL (clinical): (352) 273-8815
FAX (clinical): (352) 392-3581
TEL (research/education): (352) 273-5358
FAX (research/education): (352) 271-4518

Academic/Research Interests:

Dr. Weiner’s primary research interests involve examining the mechanisms and regulation of renal ammonia metabolism and transport.  Ammonia plays a central role in acid-base homeostasis, as it is the primary component of basal net acid excretion and changes in ammonia excretion comprise almost 90% of the renal response to acid-base alterations.  Renal ammonia transport has traditionally been believed to involve “ammonium (NH4+) trapping” and diffusive NH3 movement.  Dr. Weiner’s laboratory examines the specific mechanisms of renal NH3 movement, and has shown that, in contrast to previously thought models, that NH3 transport involves specific proteins, namely, Rh glycoproteins.  These proteins are widely expressed in ammonia transporting tissues, and Dr. Weiner’s studies, using a variety of in vivo and in vitro models, including transgenic animal models utilizing cell-specific gene deletion, have shown the central role of these proteins in renal ammonia, and thereby acid-base, homeostasis.  Dr. Weiner has presented this work in a wide variety of international symposium, including invited symposium talks at American Society of Nephrology, Korean Society of Nephrology, International Congress of Nephrology and Experimental Biology 2011.  A recent review publication from Dr. Weiner’s laboratory, entitled Role of NH3 and NH4+ transporters in renal acid-base transport, is available for free download.

Clinical Interests:

Dr. Weiner’s major clinical interests involve refractory hypertension, including specific expertise in primary hyperaldosteronism and renovascular hypertension, genetic causes of electrolyte disorders, such as Gitelman’s and Bartters’s syndrome, autosomal polycystic kidney disease, chronic kidney disease associated with organ transplantation (non-renal transplants, only). He also maintains an active practice in management of patients with chronic kidney disease of other etiologies.

Dr. Weiner was recently recognized by US News, in partnership with Castle Connolly Medical Ltd., as one of the top 1% of nephrologists in the United States. Dr. Weiner recently published the book, ID Weiner and C Adamec. The Encyclopedia of Kidney Diseases and Disorders.  New York, NY, Facts on File, Inc.  2012.

A complete listing of Dr. Weiner’s scientific journal publications is available here.