Jill W. Verlander, DVM
Jill W. Verlander, DVM
Division of Nephrology, Hypertension & Renal Transplantation
Director of College of Medicine Core Electron Microscopy Lab
1600 SW Archer Road
Room RB-167A, ARB Basement
PO Box 100224
Gainesville, FL 32610-0224
TEL: (352) 846-0820
FAX: (352) 392-5465
|BS||Newcomb College, Tulane University|
|DVM||Louisiana State University|
|Residency||University of Florida, College of Veterinary Medicine||Small Animal Internal Medicine|
|Research Fellowship||University of Florida||Nephrology|
The focus of Dr. Verlander’s research is the regulation of acid-base and electrolyte excretion by specific renal epithelial cells in the mammalian kidney. The two major current areas of investigation are: 1) the renal regulation of ammonia excretion with emphasis on recently discovered ammonia transporters, the Rh glycoproteins, Rhbg and Rhcg; and 2) the role of the chloride/bicarbonate transporter, pendrin, in regulation of fluid volume and blood pressure.
Dr. Verlander’s laboratory studies of the novel ammonia transporters, Rhbg and Rhcg, are done in collaboration with Dr. David Weiner’s laboratory. Together they examine changes in Rhbg and Rhcg protein expression and subcellular distribution induced by various physiologic stimuli or by genetically altered mouse models using immunolocalization strategies at both the light microscopic and electron microscopic level. These studies continue to expand the understanding of mechanisms of renal ammonia metabolism and excretion in acid-base regulation.
Dr. Verlander’s laboratory studies studies of pendrin are done in collaboration with Dr. Susan Wall of Emory University. They primarily focus on structural and immunolocalization studies of pendrin expression in specific intercalated cell types in mouse models. Whereas the sole role of apical chloride/bicarbonate exchange in subtypes of intercalated cells was previously thought to be in acid-base regulation, these studies have shown a novel role of pendrin in the maintenance of fluid volume and blood pressure in part via synergy with the epithelial sodium channel, ENaC. The ongoing studies focus on the mechanisms of this interaction.
Read about her research HERE
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