Dr. David Weiner’s Lab

WeinerDr. Weiner’s primary research interests involve examining the mechanisms and regulation of renal ammonia metabolism and transport.  Ammonia plays a central role in acid-base homeostasis, as it is the primary component of basal net acid excretion and changes in ammonia excretion comprise almost 90% of the renal response to acid-base alterations.  Renal ammonia transport has traditionally been believed to involve “ammonium (NH4+) trapping” and diffusive NH3 movement.  Dr. Weiner’s laboratory examines the specific mechanisms of renal NH3 movement, and has shown that, in contrast to previously thought models, that NH3 transport involves specific proteins, namely, Rh glycoproteins.  These proteins are widely expressed in ammonia transporting tissues, and Dr. Weiner’s studies, using a variety of in vivo and in vitro models, including transgenic animal models utilizing cell-specific gene deletion, have shown the central role of these proteins in renal ammonia, and thereby acid-base, homeostasis.  Dr. Weiner has presented this work in a wide variety of international symposium, including invited symposium talks at American Society of Nephrology, Korean Society of Nephrology, International Congress of Nephrology and Experimental Biology 2011.  A recent review publication from Dr. Weiner’s laboratory, entitled Role of NH3 and NH4+ transporters in renal acid-base transport, is available for free download.

A complete listing of Dr. Weiner’s scientific journal publications is available here.