Michelle L. Gumz, PhD
Michelle L. Gumz, PhD
Division of Nephrology, Hypertension & Renal Transplantation
Associate Professor of Medicine
1600 SW Archer Road
Room CG-92B, Communicore Building
PO Box 100224
Gainesville, FL 32610-0224
TEL (research/education): (352) 273-8821
FAX (research/education): (352) 392-5465
|PhD||University of Florida||Biochemistry and Molecular Biology|
|Postdoctoral fellow||Mayo Clinic Cancer Center||Tumor Biology|
|Postdoctoral fellow||University of Florida||Renal Physiology|
Dr. Gumz has a long-time interest in the molecular control of renal function. The Gumz laboratory is investigating the role of the circadian clock in the kidney. The focus is on the regulation of sodium transport in the kidney, which is critical to the control of blood pressure as well as to overall cardiovascular health. Aldosterone is a mineralocorticoid hormone that regulates sodium balance and blood pressure. As a graduate student, Dr. Gumz was the first to identify the circadian clock gene Period 1 as an aldosterone target. She has subsequently shown that Period 1 regulates transcription of alpha ENaC, the aldosterone-regulated and rate-limiting subunit of the epithelial sodium channel. Techniques commonly employed in the lab include microarray studies, real time PCR analysis, Western blotting, and analysis of DNA/protein interactions. In vitro experiments are routinely performed using several cell culture models of the renal collecting duct. Future experiments will utilize electrophysiology to measure sodium transport in these cell lines. In vivowork is done using mouse models and upcoming studies include the use of radio-telemetry to evaluate blood pressure in Period 1 knockout mice. The Gumz laboratory continues to identify novel Period 1 targets and determine how these targets contribute to the regulation of sodium transport in the kidney.
Dr. Gumz is interested in the clinical implications of circadian rhythms in human health, particularly kidney function. Many physiological processes exhibit a circadian pattern, including the sleep-wake cycle, heart beat, hormone secretion, renal blood flow, and blood pressure. Disruption of these circadian patterns can result in disease states. For instance, while blood pressure decreases (“dips”) at night in healthy individuals, “non-dipping” leads to an increased risk of cardiac death. As well, increasing evidence suggests that circadian sleep disturbances may increase the risk of kidney disease. Future studies aimed at identifying the underlying molecular mechanisms linking the circadian clock to human kidney function will be planned in collaboration with physician scientists in the Department of Medicine, including Dr. Muna Canales.
Read about her lab HERE
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