Skip to main content Skip to main menu
UF Health University of Florida
Division of Nephrology, Hypertension & Renal Transplantation Department of Medicine in the College of Medicine
Request an Appointment
Education Overview

The Role of Glutamine Synthetase in Ammonia Metabolism, Hyun-Wook Lee, PhD (W-0002)

You can watch the video lecture using the link below. After watching the video, return to this page to take the quiz and survey for credit.

https://youtu.be/tdzvGDOmqSY

YouTube CME Channel

Presented by
Hyun-Wook Lee, PhD
Assistant Scientist
UF Division of Nephrology, Hypertension & Renal Transplantation

Target Audience
Medicine faculty, fellows, residents, researchers

Program Description
This CME activity consists of an educational component (slides, audio lecture) in an electronic format, followed by an online post-test. Estimated time to complete this activity, including review of materials, is 1.5 hours.

Requirements for Successful Completion

  • This CME activity consists of an educational component (audio lecture in an electronic format, which is followed by an online post-test).
  • Certificates are awarded upon successful completion (80% proficiency) of the post-test.
  • In order to receive credit, participants must view the presentation in its entirety.
  • The University of Florida College of Medicine will report CME credit to CE Broker when applicable.
  • There is no fee to participate in this CME activity or to receive CME credit.

Learning Objectives
As a result of participation in this activity, participants should be able to:

  • Identify renal ammonia metabolism under basal conditions and in response to a variety of physiological disturbances.
  • Analyze the role of proximal tubule glutamine synthetase in renal ammonia metabolism under basal conditions and during metabolic acidosis.
  • Assess the fundamental mechanisms of renal ammonia excretion and metabolism both under basal conditions and in response to metabolic acidosis.

Faculty Disclosure
Hyun-Wook Lee has disclosed that he has no relevant financial disclosures.  No one else in a position to control content has any financial relationships to disclose.

Continuing Medical Education Credit
Accreditation: The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit: The University of Florida College of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Release Date: December 28, 2015

Expiration Date: December 28, 2016

 

CME Course Credit Registration W-0002

Name(Required)
Address(Required)

Quiz

You must score 80% in order to receive a passing grade and CME credit for the course.
1. Ammonia metabolism is a central component of basal net acid excretion, and changes in ammonia metabolism and urinary excretion are the primary component of the renal response to a variety of physiologic disturbances. Which condition is/are increased ammonia metabolism and urinary ammonia excretion?(Required)
2. Renal ammonia metabolism involves integrated functions of intrarenal ammoniagenesis and epithelial cell-specific NH3 and NH4+ transport. Which enzyme is/are involving intrarenal ammoniagenesis?(Required)
3. Glutamine synthetase is expressed in multiple distinct cell types in the kidney. Glutamine synthetase is expressed proximal tubule cells known to be involved in ammoniagenesis. Which another cell types also glutamine synthetase is expressed?(Required)
4. In multiple conditions, changes in glutamine synthetase expression are inversely related to changes in renal ammonia excretion. Which condition is/are increased glutamine synthetase expressions?(Required)
5. Another important site of glutamine synthetase expression is the liver, where it is expressed in the pericentral hepatocytes. Where glutamine synthetase is/are expressed in the perivenous hepatocyte?(Required)
6. Which of the following statements is true?(Required)
7. Which of the following statements is true under basal conditions?(Required)
8. Which of the following statements is true during metabolic acidosis?(Required)
9. Proximal tubule glutamine synthetase expression contributes to both basal and acidosis-stimulated renal ammonia metabolism.(Required)
10. Glutamine synthetase-mediated ammonia recycling is a necessary and critical component of both basal acid-base homeostasis and the renal response to metabolic acidosis.(Required)

Please fill out the CME Evaluation Survey upon completion of this course.

You will receive a confirmation email with additional information approving your course credit.