Azra Bihorac

Azra Bihorac, M.D., MS FCCM, FASN

Professor Of Medicine, Surgery And Anesthesiology And Director, Intelligent Critical Care Center

Department: MD-NEPHROLOGY
Business Phone: (352) 273-9009

Board Certifications

  • Critical Care Medicine
    American Board of Internal Medicine
  • Internal Medicine
    American Board of Internal Medicine
  • Nephrology
    American Board of Internal Medicine
  • Neurocritical Care
    United Council of Neurological Subspecialty

Clinical Profile

Specialties
  • Medicine
Subspecialties
  • Nephrology

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-5745-2863

Publications

2021
A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.696536. [PMID] 34484194.
2021
Advances in artificial intelligence and deep learning systems in ICU-related acute kidney injury.
Current opinion in critical care. 27(6):560-572 [DOI] 10.1097/MCC.0000000000000887. [PMID] 34757993.
2021
Aligning Patient Acuity with Resource Intensity after Major Surgery: A Scoping Review.
Annals of surgery. [DOI] 10.1097/SLA.0000000000005079. [PMID] 34261886.
2021
Artificial Intelligence for AKI!Now: Let’s not await Plato’s utopian republic
Kidney360. [DOI] 10.34067/kid.0003472021.
2021
Association of early initiation of dialysis with all-cause and cardiovascular mortality: A propensity score weighted analysis of the United States Renal Data System.
Hemodialysis international. International Symposium on Home Hemodialysis. 25(2):188-197 [DOI] 10.1111/hdi.12912. [PMID] 33644974.
2021
Association of Postoperative Undertriage to Hospital Wards With Mortality and Morbidity.
JAMA network open. 4(11) [DOI] 10.1001/jamanetworkopen.2021.31669. [PMID] 34757412.
2021
Bridging the artificial intelligence valley of death in surgical decision-making
Surgery. 169(4):746-748 [DOI] 10.1016/j.surg.2021.01.008. [PMID] 33608148.
2021
Building an Artificial Intelligence-Competent Surgical Workforce.
JAMA surgery. 156(6):511-512 [DOI] 10.1001/jamasurg.2021.0045. [PMID] 33688933.
2021
Cardiovascular and Renal Disease in Chronic Critical Illness
Journal of Clinical Medicine. 10(8) [DOI] 10.3390/jcm10081601. [PMID] 33918938.
2021
Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry.
Critical care medicine. [DOI] 10.1097/CCM.0000000000005232. [PMID] 34387240.
2021
Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors
Journal of Clinical Medicine. 10(15) [DOI] 10.3390/jcm10153211. [PMID] 34361995.
2021
Deep Multi-Modal Transfer Learning for Augmented Patient Acuity Assessment in the Intelligent ICU.
Frontiers in digital health. 3 [DOI] 10.3389/fdgth.2021.640685. [PMID] 33718920.
2021
Development of a Theory-Informed Behavior Change Intervention to Reduce Inappropriate Prescribing of Nephrotoxins and Renally Eliminated Drugs.
The Annals of pharmacotherapy. 55(12):1474-1485 [DOI] 10.1177/10600280211009567. [PMID] 33855858.
2021
Equity and Artificial Intelligence in Surgical Care.
JAMA surgery. 156(6):509-510 [DOI] 10.1001/jamasurg.2020.7208. [PMID] 33625504.
2021
Executive summary of the artificial intelligence in surgery series
Surgery. [DOI] 10.1016/j.surg.2021.10.047. [PMID] 34815097.
2021
Intraoperative hypotension and complications after vascular surgery: A scoping review
Surgery. 170(1):311-317 [DOI] 10.1016/j.surg.2021.03.054. [PMID] 33972092.
2021
Machine Learning Applications in Solid Organ Transplantation and Related Complications.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.739728. [PMID] 34603324.
2021
Metabolomic Profiling for Diagnosis and Prognostication in Surgery: A Scoping Review.
Annals of surgery. 273(2):258-268 [DOI] 10.1097/SLA.0000000000003935. [PMID] 32482979.
2021
Older adults demonstrate biomarker evidence of the persistent inflammation, immunosuppression and catabolism syndrome (PICS) after sepsis.
The journals of gerontology. Series A, Biological sciences and medical sciences. [DOI] 10.1093/gerona/glab080. [PMID] 33721883.
2021
Optimizing predictive strategies for acute kidney injury after major vascular surgery.
Surgery. 170(1):298-303 [DOI] 10.1016/j.surg.2021.01.030. [PMID] 33648766.
2021
Pain Action Unit Detection in Critically Ill Patients.
Proceedings : Annual International Computer Software and Applications Conference. COMPSAC. 2021:645-651 [DOI] 10.1109/compsac51774.2021.00094. [PMID] 34723289.
2021
Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative
Nature Reviews Nephrology. 17(9):605-618 [DOI] 10.1038/s41581-021-00418-2. [PMID] 33976395.
2021
Pro Re Nata Antihypertensive Medications and Adverse Outcomes in Hospitalized Patients: A Propensity-Matched Cohort Study.
Hypertension (Dallas, Tex. : 1979). 78(2):516-524 [DOI] 10.1161/HYPERTENSIONAHA.121.17279. [PMID] 34148363.
2021
Reinforcement learning in surgery
Surgery. 170(1):329-332 [DOI] 10.1016/j.surg.2020.11.040. [PMID] 33436272.
2021
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Shock (Augusta, Ga.). 55(5):587-595 [DOI] 10.1097/SHK.0000000000001671. [PMID] 33021571.
2021
The effect of non-pharmacologic strategies on prevention or management of intensive care unit delirium: a systematic review
F1000Research. 9 [DOI] 10.12688/f1000research.25769.2.
2021
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35(2) [DOI] 10.1096/fj.202002150R. [PMID] 33140449.
2020
Added Value of Intraoperative Data for Predicting Postoperative Complications: The MySurgeryRisk PostOp Extension
Journal of Surgical Research. 254:350-363 [DOI] 10.1016/j.jss.2020.05.007. [PMID] 32531520.
2020
Artificial Intelligence and Surgical Decision-making.
JAMA surgery. 155(2):148-158 [DOI] 10.1001/jamasurg.2019.4917. [PMID] 31825465.
2020
Artificial intelligence approaches to improve kidney care
Nature Reviews Nephrology. 16(2):71-72 [DOI] 10.1038/s41581-019-0243-3. [PMID] 31873197.
2020
Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study.
Critical care explorations. 2(12) [DOI] 10.1097/CCE.0000000000000278. [PMID] 33251517.
2020
Automated Detection of Rest Disruptions in Critically Ill Patients.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2020:5450-5454 [DOI] 10.1109/EMBC44109.2020.9175252. [PMID] 33019213.
2020
Cardiovascular death and progression to end-stage renal disease after major surgery in elderly patients
BJS Open. 4(1):145-156 [DOI] 10.1002/bjs5.50232. [PMID] 32011817.
2020
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery. [DOI] 10.1097/SLA.0000000000004360. [PMID] 33196489.
2020
Contemporary Management of Severe Acute Kidney Injury and Refractory Cardiorenal Syndrome: JACC Council Perspectives.
Journal of the American College of Cardiology. 76(9):1084-1101 [DOI] 10.1016/j.jacc.2020.06.070. [PMID] 32854844.
2020
COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup
Nature Reviews Nephrology. 16(12):747-764 [DOI] 10.1038/s41581-020-00356-5. [PMID] 33060844.
2020
Decision analysis and reinforcement learning in surgical decision-making.
Surgery. 168(2):253-266 [DOI] 10.1016/j.surg.2020.04.049. [PMID] 32540036.
2020
Delayed interhospital transfer of critically ill patients with surgical sepsis.
The journal of trauma and acute care surgery. 88(1):169-175 [DOI] 10.1097/TA.0000000000002476. [PMID] 31856021.
2020
Discovery and Validation of Urinary Molecular Signature of Early Sepsis.
Critical care explorations. 2(10) [DOI] 10.1097/CCE.0000000000000195. [PMID] 33063018.
2020
Human Activity Recognition Using Inertial, Physiological and Environmental Sensors: A Comprehensive Survey
IEEE Access. 8:210816-210836 [DOI] 10.1109/access.2020.3037715. [PMID] 33344100.
2020
ICU Delirium-Prediction Models: A Systematic Review.
Critical care explorations. 2(12) [DOI] 10.1097/CCE.0000000000000296. [PMID] 33354672.
2020
Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study.
Intensive care medicine. 46(5):943-953 [DOI] 10.1007/s00134-019-05919-0. [PMID] 32025755.
2020
Improving the Intensive Care Patient Experience With Virtual Reality-A Feasibility Study.
Critical care explorations. 2(6) [DOI] 10.1097/CCE.0000000000000122. [PMID] 32695991.
2020
Intelligent, Autonomous Machines in Surgery
Journal of Surgical Research. 253:92-99 [DOI] 10.1016/j.jss.2020.03.046. [PMID] 32339787.
2020
Joint Distribution and Transitions of Pain and Activity in Critically Ill Patients.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2020:4534-4538 [DOI] 10.1109/EMBC44109.2020.9176453. [PMID] 33019002.
2020
Mysteries, Epistemological Modesty, and Artificial Intelligence in Surgery.
Frontiers in artificial intelligence. 2 [DOI] 10.3389/frai.2019.00032. [PMID] 33117989.
2020
Opportunities for machine learning to improve surgical ward safety.
American journal of surgery. 220(4):905-913 [DOI] 10.1016/j.amjsurg.2020.02.037. [PMID] 32127174.
2020
Pain and Physical Activity Association in Critically Ill Patients.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2020:5696-5699 [DOI] 10.1109/EMBC44109.2020.9176227. [PMID] 33019268.
2020
Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup
Nature Reviews Nephrology. [DOI] 10.1038/s41581-020-00372-5. [PMID] 33139940.
2020
Quality of care after AKI development in the hospital: Consensus from the 22nd Acute Disease Quality Initiative (ADQI) conference.
European journal of internal medicine. 80:45-53 [DOI] 10.1016/j.ejim.2020.04.056. [PMID] 32616340.
2020
Reactive Artificial Intelligence Using Big Data in the Era of Precision Medicine-Reply.
JAMA surgery. 155(7):671-672 [DOI] 10.1001/jamasurg.2020.0856. [PMID] 32374380.
2020
The effect of non-pharmacologic strategies on prevention or management of intensive care unit delirium: a systematic review
F1000Research. 9 [DOI] 10.12688/f1000research.25769.1.
2020
The impact of environmental risk factors on delirium and benefits of noise and light modifications: a scoping review
F1000Research. 9 [DOI] 10.12688/f1000research.25901.1.
2019
Artificial intelligence to predict AKI: is it a breakthrough?
Nature reviews. Nephrology. 15(11):663-664 [DOI] 10.1038/s41581-019-0203-y. [PMID] 31506607.
2019
Comparing clinical judgment with the MySurgeryRisk algorithm for preoperative risk assessment: A pilot usability study
Surgery. 165(5):1035-1045 [DOI] 10.1016/j.surg.2019.01.002. [PMID] 30792011.
2019
DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning
Scientific Reports. 9(1) [DOI] 10.1038/s41598-019-38491-0. [PMID] 30755689.
2019
Extended vertical lists for temporal pattern mining from multivariate time series.
Expert systems. 36(5) [DOI] 10.1111/exsy.12448. [PMID] 33162636.
2019
External Validation of the qSOFA Score in Emergency Department Patients With Pneumonia.
The Journal of emergency medicine. 57(6):755-764 [DOI] 10.1016/j.jemermed.2019.08.043. [PMID] 31735660.
2019
Improved predictive models for acute kidney injury with IDEA: Intraoperative Data Embedded Analytics
PLOS ONE. 14(4) [DOI] 10.1371/journal.pone.0214904. [PMID] 30947282.
2019
Intelligent ICU for Autonomous Patient Monitoring Using Pervasive Sensing and Deep Learning.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-44004-w. [PMID] 31142754.
2019
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Critical care (London, England). 23(1) [DOI] 10.1186/s13054-019-2628-x. [PMID] 31722736.
2019
MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery.
Annals of surgery. 269(4):652-662 [DOI] 10.1097/SLA.0000000000002706. [PMID] 29489489.
2019
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Critical care medicine. 47(11):e919-e929 [DOI] 10.1097/CCM.0000000000003926. [PMID] 31389840.
2019
Persistent inflammation and anemia among critically ill septic patients.
The journal of trauma and acute care surgery. 86(2):260-267 [DOI] 10.1097/TA.0000000000002147. [PMID] 30489504.
2019
Quality Improvement Goals for Acute Kidney Injury.
Clinical journal of the American Society of Nephrology : CJASN. 14(6):941-953 [DOI] 10.2215/CJN.01250119. [PMID] 31101671.
2019
Response to Comment on “MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery”.
Annals of surgery. 269(6) [DOI] 10.1097/SLA.0000000000002884. [PMID] 31082924.
2019
Role of Wearable Accelerometer Devices in Delirium Studies: A Systematic Review.
Critical care explorations. 1(9) [DOI] 10.1097/CCE.0000000000000027. [PMID] 32166280.
2019
Serial Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 and the Prognosis for Acute Kidney Injury over the Course of Critical Illness
Cardiorenal Medicine. 9(6):358-369 [DOI] 10.1159/000502837.
2019
The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.
Critical care medicine. 47(4):566-573 [DOI] 10.1097/CCM.0000000000003655. [PMID] 30664526.
2019
Use of Artificial Intelligence to Represent Emergent Systems and Augment Surgical Decision-making.
JAMA surgery. 154(9):791-792 [DOI] 10.1001/jamasurg.2019.1510. [PMID] 31215974.
2018
Activity and Circadian Rhythm of Sepsis Patients in the Intensive Care Unit.
… IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics. 2018:17-20 [DOI] 10.1109/BHI.2018.8333359. [PMID] 30411088.
2018
Autonomous detection of disruptions in the intensive care unit using deep mask RCNN.
Conference on Computer Vision and Pattern Recognition Workshops. IEEE Computer Society Conference on Computer Vision and Pattern Recognition. Workshops. 2018:1944-1946 [DOI] 10.1109/CVPRW.2018.00241. [PMID] 30931175.
2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery. 84(2):342-349 [DOI] 10.1097/TA.0000000000001758. [PMID] 29251709.
2018
Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group.
Journal of the American Heart Association. 7(11) [DOI] 10.1161/JAHA.118.008834. [PMID] 29858368.
2018
Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01511. [PMID] 30013565.
2018
Comparison of Gaussian Processes Methods to Linear methods for Imputation of Sparse Physiological Time Series.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2018:4106-4109 [DOI] 10.1109/EMBC.2018.8513303. [PMID] 30441259.
2018
Deep EHR: A Survey of Recent Advances in Deep Learning Techniques for Electronic Health Record (EHR) Analysis
IEEE Journal of Biomedical and Health Informatics. 22(5):1589-1604 [DOI] 10.1109/jbhi.2017.2767063.
2018
Deep EHR: A Survey of Recent Advances in Deep Learning Techniques for Electronic Health Record (EHR) Analysis
IEEE Journal of Biomedical and Health Informatics. 22(5):1589-1604 [DOI] 10.1109/jbhi.2017.2767063.
2018
Epidemiology, outcomes, and management of acute kidney injury in the vascular surgery patient
Journal of Vascular Surgery. 68(3):916-928 [DOI] 10.1016/j.jvs.2018.05.017. [PMID] 30146038.
2018
Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.
Shock (Augusta, Ga.). 49(3):249-258 [DOI] 10.1097/SHK.0000000000000981. [PMID] 28885387.
2018
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.00595. [PMID] 29670613.
2018
Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II.
Critical care medicine. 46(6):949-957 [DOI] 10.1097/CCM.0000000000003092. [PMID] 29509568.
2018
Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery
Surgery. 164(2):178-184 [DOI] 10.1016/j.surg.2018.04.011. [PMID] 29807651.
2018
The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients.
The journal of trauma and acute care surgery. 85(2):247-255 [DOI] 10.1097/TA.0000000000001921. [PMID] 29613958.
2018
Virtual Reality and Human Consciousness: The Use of Immersive Environments in Delirium Therapy.
Technoetic arts : a journal of speculative research. 16(1):75-83 [DOI] 10.1386/tear.16.1.75_1. [PMID] 33082715.
2017
Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup.
Nature reviews. Nephrology. 13(4):241-257 [DOI] 10.1038/nrneph.2017.2. [PMID] 28239173.
2017
Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure.
Shock (Augusta, Ga.). 48(1):5-10 [DOI] 10.1097/SHK.0000000000000825. [PMID] 28009772.
2017
Acute kidney injury: Precision perioperative care protects the kidneys.
Nature reviews. Nephrology. 14(1):8-10 [DOI] 10.1038/nrneph.2017.170. [PMID] 29234162.
2017
D.R.E.A.M.S: (Digital Rehabilitation Environment-Altering Medical System).
SeGAH … IEEE … International Conference on Serious Games and Applications for Health : book of proceedings. IEEE International Conference on Serious Games and Applications for Health. 2017 [DOI] 10.1109/SeGAH.2017.7939293. [PMID] 29863184.
2017
Delirium Prediction using Machine Learning Models on Preoperative Electronic Health Records Data.
Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering. 2017:568-573 [DOI] 10.1109/BIBE.2017.00014. [PMID] 30393788.
2017
Intelligent Perioperative System: Towards Real-time Big Data Analytics in Surgery Risk Assessment.
DASC-PICom-DataCom-CyberSciTech 2017 : 2017 IEEE 15th International Conference on Dependable, Autonomic and Secure Computing ; 2017 IEEE 15th International Conference on Pervasive Intelligence and Computing ; 2017 IEEE 3rd International…. 2017:1254-1259 [DOI] 10.1109/DASC-PICom-DataCom-CyberSciTec.2017.201. [PMID] 30272054.
2017
Kidney and Brain, an Unbroken Chain
American Journal of Respiratory and Critical Care Medicine. 195(12):1546-1548 [DOI] 10.1164/rccm.201611-2371ed.
2017
Kidney and Brain, an Unbroken Chain
American Journal of Respiratory and Critical Care Medicine. 195(12):1546-1548 [DOI] 10.1164/rccm.201611-2371ed.
2017
Mortality and cost of acute and chronic kidney disease after cardiac surgery.
Current opinion in anaesthesiology. 30(1):113-117 [DOI] 10.1097/ACO.0000000000000422. [PMID] 27841788.
2017
Optimal Role of the Nephrologist in the Intensive Care Unit
Blood Purification. 43(1-3):68-77 [DOI] 10.1159/000452317. [PMID] 27923227.
2017
Perioperative Acute Kidney Injury: Risk Factors and Predictive Strategies.
Critical care clinics. 33(2):379-396 [DOI] 10.1016/j.ccc.2016.12.008. [PMID] 28284301.
2017
Recovery after Acute Kidney Injury.
American journal of respiratory and critical care medicine. 195(6):784-791 [DOI] 10.1164/rccm.201604-0799OC. [PMID] 27635668.
2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open. 7(7) [DOI] 10.1136/bmjopen-2016-015136. [PMID] 28765125.
2017
The Impact of Changes in Medicare’s Physician Payment System on Critical Care.
Critical connections : the complete news source for critical care professionals. 15:18-19 [PMID] 28956027.
View on: PubMed
2016
Acute and Chronic Kidney Disease and Cardiovascular Mortality After Major Surgery.
Annals of surgery. 264(6):987-996 [PMID] 26756753.
View on: PubMed
2016
Application of Machine Learning Techniques to High-Dimensional Clinical Data to Forecast Postoperative Complications
PLOS ONE. 11(5) [DOI] 10.1371/journal.pone.0155705. [PMID] 27232332.
2016
Authors’ reply re:Acute kidney injury in major gynaecological surgery: an observational study.
BJOG : an international journal of obstetrics and gynaecology. 123(7) [DOI] 10.1111/1471-0528.13936. [PMID] 27206044.
2016
Cardiovascular-Specific Mortality and Kidney Disease in Patients Undergoing Vascular Surgery.
JAMA surgery. 151(5):441-50 [DOI] 10.1001/jamasurg.2015.4526. [PMID] 26720406.
2016
Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 68(1):19-28 [DOI] 10.1053/j.ajkd.2015.12.033. [PMID] 26948834.
2016
Establishing a continuum of acute kidney injury – tracing AKI using data source linkage and long-term follow-up: Workgroup Statements from the 15th ADQI Consensus Conference.
Canadian journal of kidney health and disease. 3 [DOI] 10.1186/s40697-016-0102-0. [PMID] 26925249.
2016
Faculty Opinions recommendation of Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature. [DOI] 10.3410/f.726319697.793521463.
2016
Long-Term Outcomes for Different Forms of Stress Cardiomyopathy After Surgical Treatment for Subarachnoid Hemorrhage.
Anesthesia and analgesia. 122(5):1594-602 [DOI] 10.1213/ANE.0000000000001231. [PMID] 27007075.
2016
Mortality and Cost of Acute and Chronic Kidney Disease after Vascular Surgery
Annals of Vascular Surgery. 30:72-81.e2 [DOI] 10.1016/j.avsg.2015.04.092. [PMID] 26187703.
2016
Perioperative Acute Kidney Injury-Reply.
JAMA surgery. 151(8) [DOI] 10.1001/jamasurg.2016.0470. [PMID] 27050480.
2016
Preoperative assessment of the risk for multiple complications after surgery.
Surgery. 160(2):463-72 [DOI] 10.1016/j.surg.2016.04.013. [PMID] 27238354.
2016
The Pattern of Longitudinal Change in Serum Creatinine and 90-Day Mortality After Major Surgery.
Annals of surgery. 263(6):1219-1227 [DOI] 10.1097/SLA.0000000000001362. [PMID] 26181482.
2016
TIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients.
The journal of trauma and acute care surgery. 80(2):243-9 [DOI] 10.1097/TA.0000000000000912. [PMID] 26816218.
2016
Variant Neurogenic Stunned Myocardium in a Young Female After Subarachnoid Hemorrhage.
A & A case reports. 6(1):10-3 [DOI] 10.1213/XAA.0000000000000172. [PMID] 26422453.
2015
A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged.
Journal of immunology (Baltimore, Md. : 1950). 195(5):2396-407 [DOI] 10.4049/jimmunol.1500984. [PMID] 26246141.
2015
Acute kidney injury in 2014: a step towards understanding mechanisms of renal repair.
Nature reviews. Nephrology. 11(2):74-5 [DOI] 10.1038/nrneph.2014.245. [PMID] 25561080.
2015
Acute kidney injury in major gynaecological surgery: an observational study.
BJOG : an international journal of obstetrics and gynaecology. 122(10):1340-8 [DOI] 10.1111/1471-0528.13026. [PMID] 25134440.
2015
Acute Kidney Injury in the Surgical Patient.
Critical care clinics. 31(4):705-23 [DOI] 10.1016/j.ccc.2015.06.007. [PMID] 26410139.
2015
Acute Kidney Injury in the Surgical Patient: Recognition and Attribution
Nephron. 131(2):118-122 [DOI] 10.1159/000439387. [PMID] 26344954.
2015
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.
Critical care (London, England). 19 [DOI] 10.1186/s13054-015-0788-x. [PMID] 25880307.
2015
Clostridium difficile Infections after Blunt Trauma: A Different Patient Population?
Surgical infections. 16(4):421-7 [DOI] 10.1089/sur.2013.141. [PMID] 26207402.
2015
Cost and Mortality Associated With Postoperative Acute Kidney Injury.
Annals of surgery. 261(6):1207-14 [DOI] 10.1097/SLA.0000000000000732. [PMID] 24887982.
2015
Critical Care Delivery and ICU Structure-The Elephant in the Room.
Critical care medicine. 43(12):e590-1 [DOI] 10.1097/CCM.0000000000001252. [PMID] 26575673.
2015
Early Angiogenic Balance and Adverse Long-Term Outcomes in Sepsis
Shock. 43(6, 1)
2015
Faculty Opinions recommendation of Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature. [DOI] 10.3410/f.725372232.793504700.
2015
Guiding AKI Prevention Using Biomarkers.
Critical connections : the complete news source for critical care professionals. 14(2):1-11 [PMID] 29034373.
View on: PubMed
2015
Human Myeloid Derived Suppressor Cells Induce Immune Suppression After Severe Sepsis
Shock. 43(6, 1)
2015
Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit.
PloS one. 10(5) [DOI] 10.1371/journal.pone.0126895. [PMID] 26010247.
2015
Tissue Inhibitor Metalloproteinase-2 (TIMP-2)⋅IGF-Binding Protein-7 (IGFBP7) Levels Are Associated with Adverse Long-Term Outcomes in Patients with AKI.
Journal of the American Society of Nephrology : JASN. 26(7):1747-54 [DOI] 10.1681/ASN.2014060556. [PMID] 25535301.
2014
A better understanding of why murine models of trauma do not recapitulate the human syndrome.
Critical care medicine. 42(6):1406-13 [DOI] 10.1097/CCM.0000000000000222. [PMID] 24413577.
2014
Advanced Age Is An Independent Predictor of Complicated Outcomes and Mortality Among Severely Injured Pateints in Hemorrhagic Shock
Shock. 41(2)
2014
Aged mice are unable to mount an effective myeloid response to sepsis.
Journal of immunology (Baltimore, Md. : 1950). 192(2):612-22 [DOI] 10.4049/jimmunol.1302109. [PMID] 24337739.
2014
Genomic Analysis of Individual Leukocyte Populations After Severe Trauma
Shock. 41(2)
2014
Gram stain can be used to safely discontinue vancomycin therapy for early pneumonia in the trauma intensive care unit.
The American surgeon. 80(12):1277-9 [PMID] 25513932.
View on: PubMed
2014
Insurance status is associated with treatment allocation and outcomes after subarachnoid hemorrhage.
PloS one. 9(8) [DOI] 10.1371/journal.pone.0105124. [PMID] 25141303.
2014
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.
The journal of trauma and acute care surgery. 76(1):21-9; discussion 29 [DOI] 10.1097/TA.0b013e3182ab1ab5. [PMID] 24368353.
2014
The Lung Neutrophil Transcriptome After Trauma Influences the Worse Outcomes of the Old To Pneumonia
Critical Care Medicine. 42(12, S)
2014
Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication.
American journal of respiratory and critical care medicine. 189(8):932-9 [DOI] 10.1164/rccm.201401-0077OC. [PMID] 24559465.
2013
A genomic analysis of Clostridium difficile infections in blunt trauma patients.
The journal of trauma and acute care surgery. 74(1):334-8 [DOI] 10.1097/TA.0b013e3182789426. [PMID] 23271108.
2013
Acute kidney injury is associated with early cytokine changes after trauma.
The journal of trauma and acute care surgery. 74(4):1005-13 [DOI] 10.1097/TA.0b013e31828586ec. [PMID] 23511138.
2013
Acute kidney injury is surprisingly common and a powerful predictor of mortality in surgical sepsis.
The journal of trauma and acute care surgery. 75(3):432-8 [DOI] 10.1097/TA.0b013e31829de6cd. [PMID] 24089113.
2013
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients.
Critical care medicine. 41(5):1175-85 [DOI] 10.1097/CCM.0b013e318277131c. [PMID] 23388514.
2013
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury.
Critical care (London, England). 17(1) [DOI] 10.1186/cc12503. [PMID] 23388612.
2013
National surgical quality improvement program underestimates the risk associated with mild and moderate postoperative acute kidney injury.
Critical care medicine. 41(11):2570-83 [DOI] 10.1097/CCM.0b013e31829860fc. [PMID] 23928835.
2012
Creatinine Clearance Predicts Poor Outcome in Emergency Department Presentation of Pediatric Sepsis
Critical Care Medicine. 40:U141-U142
2012
Effect of Postoperative Acute Kidney Injury On Hospital Cost
Critical Care Medicine. 40
2012
Gram Stain Can Be Used To Safely Discontinue Vancomycin Therapy for Early Pneumonia in the Trauma Icu
Critical Care Medicine. 40:U114-U115
2012
Hypdxia-Induced Angiogenic Factors, Progenitor Endothelial Cells and Urinary Hypdxic Markers as Early Markers of Endothelial Injury in Hemorrhagic Shock (Hypper)
Shock. 37:59-60
2012
Impact of Pharmacologic Options for Drug-Induced Hypertension in Acute Ischemic Stroke On Icu and Hopsital Length of Stay
Critical Care Medicine. 40
2012
Mathematical Modeling of the Association Between the Pattern of Change in Postoperative Serum Creatinine and Hospital Mortality
Critical Care Medicine. 40
2012
Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.
The journal of trauma and acute care surgery. 72(6):1491-501 [DOI] 10.1097/TA.0b013e318256e000. [PMID] 22695412.
2012
Primary payer status is associated with the use of nerve block placement for ambulatory orthopedic surgery.
Regional anesthesia and pain medicine. 37(3):254-61 [DOI] 10.1097/AAP.0b013e31824889b6. [PMID] 22430024.
2012
Primary Payer Status Is Associated With Treatment Allocation and Clinical Outcomes After Admission for Non-Traumatic Subarachnoid Hemorrhage
Critical Care Medicine. 40
2012
Regional anesthesia as compared with general anesthesia for surgery in geriatric patients with hip fracture: does it decrease morbidity, mortality, and health care costs? Results of a single-centered study.
Pain medicine (Malden, Mass.). 13(7):948-56 [DOI] 10.1111/j.1526-4637.2012.01402.x. [PMID] 22758782.
2012
The acute immunological response to blood transfusion is influenced by polymicrobial sepsis.
Shock (Augusta, Ga.). 38(6):598-606 [DOI] 10.1097/SHK.0b013e318273621a. [PMID] 23143057.
2012
Use of machine-learning classifiers to predict requests for preoperative acute pain service consultation.
Pain medicine (Malden, Mass.). 13(10):1347-57 [DOI] 10.1111/j.1526-4637.2012.01477.x. [PMID] 22958457.
2011
Early blood biomarkers predict organ injury and resource utilization following complex cardiac surgery.
The Journal of surgical research. 168(2):168-72 [DOI] 10.1016/j.jss.2009.09.023. [PMID] 20031165.
2011
The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States.
PloS one. 6(4) [DOI] 10.1371/journal.pone.0018890. [PMID] 21573031.
2010
Acute kidney injury and long-term outcomes: more to learn.
Kidney international. 77(8) [DOI] 10.1038/ki.2009.554. [PMID] 20354556.
2010
Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients.
Annals of surgery. 252(1):158-65 [DOI] 10.1097/SLA.0b013e3181deb6bc. [PMID] 20562612.
2010
Long-term mortality associated with acute kidney injury requiring dialysis.
JAMA. 303(3):229; author reply 229-30 [DOI] 10.1001/jama.2009.1878. [PMID] 20085947.
2009
Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery.
Circulation. 119(18):2444-53 [DOI] 10.1161/CIRCULATIONAHA.108.800011. [PMID] 19398670.
2009
Long-term risk of mortality and acute kidney injury during hospitalization after major surgery.
Annals of surgery. 249(5):851-8 [DOI] 10.1097/SLA.0b013e3181a40a0b. [PMID] 19387314.
2009
Successful thrombolytic therapy for acute kidney injury secondary to thrombosis of suprarenal inferior vena cava filter.
Journal of thrombosis and thrombolysis. 28(4):500-5 [DOI] 10.1007/s11239-009-0359-6. [PMID] 19521667.
2008
Early Blood Biomarkers Predict Organ Injury and Resource Utilization Following Complex Cardiac Surgery
Journal of the American College of Surgeons. 207(3) [DOI] 10.1016/j.jamcollsurg.2008.06.042.
2008
Rifle Criteria in Aortic Arch Surgery: the Further Role of Surgical Subgroup – Reply
Journal of Thoracic and Cardiovascular Surgery. 136(1) [DOI] 10.1016/j.jtcvs.2008.03.012.
2007
Exit of catheter lock solutions from double lumen acute haemodialysis catheters–an in vitro study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 22(12):3533-7 [PMID] 17898024.
View on: PubMed
2007
RIFLE criteria for acute kidney injury in aortic arch surgery.
The Journal of thoracic and cardiovascular surgery. 134(6):1554-60; discussion 1560 [PMID] 18023682.
View on: PubMed
2007
The rise and fall of natriuretic peptides in acute kidney injury: a misunderstood relationship?
Reviews in cardiovascular medicine. 8 Suppl 5:S32-7 [PMID] 18192953.
View on: PubMed
2005
Circulating endothelial cells are associated with future vascular events in hemodialysis patients.
Kidney international. 67(3):1078-83 [PMID] 15698448.
View on: PubMed
2005
Continuous venovenous hemofiltration with citrate-based replacement fluid: efficacy, safety, and impact on nutrition.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 46(5):908-18 [PMID] 16253732.
View on: PubMed
2003
Circulating endothelial cells as potential markers of the state of the endothelium in hemodialysis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 42(4):704-12 [PMID] 14520620.
View on: PubMed
2002
Circulating endothelial cells: tea leaves for renal disease.
American journal of physiology. Renal physiology. 283(1):F11-9 [PMID] 12060582.
View on: PubMed
2002
QT dispersion in hemodialysis and CAPD patients.
Nephron. 91(4):739-41 [PMID] 12138280.
View on: PubMed
2002
QT dispersion in renal transplant recipients.
Nephron. 91(2):250-4 [PMID] 12053061.
View on: PubMed
2002
Uncontrolled hypertension due to volume overload contributes to higher left ventricular mass index in CAPD patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 17(9):1661-6 [PMID] 12198220.
View on: PubMed
2001
Technical survival of CAPD catheters: comparison between percutaneous and conventional surgical placement techniques.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 16(9):1893-9 [PMID] 11522875.
View on: PubMed
2000
Association between salt sensitivity and target organ damage in essential hypertension.
American journal of hypertension. 13(8):864-72 [PMID] 10950394.
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2000
Left ventricular hypertrophy and angiotensin-converting enzyme gene polymorphism in renal allograft recipients.
Transplantation proceedings. 32(3):542-4 [PMID] 10812105.
View on: PubMed
2000
Severe hyperkalemia in two renal transplant recipients treated with standard dose of trimethoprim-sulfamethoxazole.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 36(3) [PMID] 10977811.
View on: PubMed
2000
The impact of the earthquake in northwestern Turkey on the continuous ambulatory peritoneal dialysis patients who were living in the earthquake zone.
Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 16:182-5 [PMID] 11045289.
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1999
Does colchicine also induce a clearance of the established amyloid deposits?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 14(4):1042-3 [PMID] 10328512.
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1999
Tetracycline-induced acute interstitial nephritis as a cause of acute renal failure.
Nephron. 81(1):72-5 [PMID] 9884423.
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1998
Association between left atrial enlargement and target organ damage in essential hypertension.
American journal of hypertension. 11(6 Pt 1):732-3 [PMID] 9657634.
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1998
Perirenal haematoma as the presenting feature of polyarteritis nodosa: one more case from Turkey.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 13(3):812-3 [PMID] 9550682.
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1997
Mild-to-moderate hypertension and apolipoprotein E gene polymorphism.
American journal of hypertension. 10(7 Pt 1):827-8 [PMID] 9234841.
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The Effect of Non-Pharmacologic Strategies on Prevention or Management of Intensive Care Unit Delirium: A Systematic Review
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Grants

Sep 2021 ACTIVE
Informing the Emergency Care of Septic Shock Patients: A Novel Application of Data-Driven Analytics
Role: Other
Funding: NATL INST OF HLTH NIGMS
Jun 2021 ACTIVE
(MEnD-AKI) Multicenter Implementation of an Electronic Decision Support System for Drug-Associated AKI
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH MED CNTR via NATL INST OF HLTH NIDDK
May 2021 ACTIVE
ADAPT: Autonomous Delirium Monitoring and Adaptive Prevention
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2021 ACTIVE
Intelligent Intensive Care Unit (I2CU): Pervasive Sensing and Artificial Intelligence for Augmented Clinical Decision-making
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Jan 2021 ACTIVE
Advancing Racial Justice Through Inclusion, Diversity, Equity, and Access at the University of Florida
Role: Project Manager
Funding: UF RESEARCH
May 2020 ACTIVE
Development and Validation of Computational Algorithms to Assess Kidney Health in Electronic Health Records
Role: Other
Funding: NATL INST OF HLTH NIDDK
Feb 2019 ACTIVE
Autonomous Pain Recognition in Non-Verbal and Critically Ill Patients
Role: Co-Investigator
Funding: NATL INST OF HLTH NIBIB
Jun 2018 – May 2020
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Feb 2018 – Feb 2021
STandard versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI): A Multi-Centre, Randomized, Controlled Trial
Role: Principal Investigator
Funding: ST. MICHAELS HOSPITAL via CANADIAN INST OF HLTH RES
Jun 2017 – May 2018
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Mar 2016 ACTIVE
Integrating data, algorithms and clinical reasoning for surgical risk assessment
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Oct 2015 – Oct 2018
A Phase 3, Placebo-Controlled, Randomized, Double-Blind, Multi-Center Study of LJPC-501 in Patients with Catecholamine-Resistant Hypotension (CRH)
Role: Principal Investigator
Funding: LA JOLLA PHARMACEUTICAL CO
Jun 2015 – May 2016
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
May 2014 – Apr 2017
Network analysis of urinary molecular signature complements clinical data to predict postoperative acute kidney injury
Role: Principal Investigator
Funding: HEERMANN ANESTHESIA FOU, I
May 2013 – Mar 2016
Identification and Validation of Biomarkers of Acute Kidney Injury Recovery-Ruby
Role: Principal Investigator
Funding: ASTUTE MEDICAL
Oct 2010 – Oct 2016
Evaluation of novel Biomakrers from Acute III Patients at Risk for Acute Kidney Injury
Role: Principal Investigator
Funding: ASTUTE MEDICAL

Education

Master of Science – Health Sciences in Clinical Research
2011 · University of Florida
Fellowship – Critical Care Medicine
2006 · University of Florida
Residency – Internal Medicine
2005 · University of Florida
Fellowship – Nephrology
2003 · University of Florida
Medical Degree
1990 · University of Sarajevo

Teaching Profile

Courses Taught
2018
MDT7090 Elective Topics
2012-2014
BMS4905 Medical Sciences Senior Research
2011,2014
PHC7979 Advanced Research
2009
IDH4917 Undergrad Research

Contact Details

Phones:
Business:
(352) 273-9009