Michelle L Gumz,
Associate Professor
Department:
MD-PHYSIOLOGY FUNCTIONAL GENOM
Business Phone:
(352) 273-6887
Business Email:
michelle.gumz@medicine.ufl.edu
About Michelle L Gumz
Additional Positions:
Robert and Mary Cade Professor of Physiology
2021 – Current
·
University of Florida
Associate Director, Center for Integrative Cardiovascular and Metabolic Diseases
2018 – Current
·
University of Florida
Teaching Profile
Courses Taught
2013,2020
BCH6208 Advanced Metabolism: Regulation of Key Reactions in Carbohydrate and Lipid Metabolism
2015-2023
GMS6491 Journal Club in Physiology
2020
BCH6207 Advanced Metabolism: Role of Membranes in Signal Transduction and Metabolic Control
2013-2018,2020-2023
BCH6206 Advanced Metabolism
2013-2023
BCH5413 Mammalian Molecular Biology and Genetics
2013-2014,2016-2021,2020-2023,2023
BCH4905 Biochemistry Senior Research
2014-2019,2021-2022
BCH6415 Advanced Molecular and Cell Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
BMS6638C Kidney & Urinary Tract
2014-2015,2022-2023
BCH6209 Advanced Metabolism: Regulation of Key Reactions in Amino Acid and Nucleotide Metabolism
2021
VME6934 Topics in Veterinary Medical Sciences
Research Profile
Dr. Gumz has a long-time interest in the molecular control of renal function. The Gumz laboratory is investigating the role of the molecular circadian clock in the kidney with the long term goal of determining how the clock in the kidney contributes to the control of blood pressure as well as to overall cardiovascular health. Aldosterone is a mineralocorticoid hormone that regulates sodium balance and blood pressure. As a graduate student, Dr. Gumz was the first to identify the circadian clock gene Period 1 as an aldosterone target. She has subsequently shown that Period 1 regulates transcription of alpha ENaC, the aldosterone-regulated and rate-limiting subunit of the epithelial sodium channel. New areas of study include cross talk between the kidney clock and other tissue clocks and sex differences in the function of Period 1 and Bmal1, another critical core clock gene.
Open Researcher and Contributor ID (ORCID)
0000-0002-1342-0878
Publications
2022
A wrinkle in time: circadian biology in pulmonary vascular health and disease
American Journal of Physiology-Lung Cellular and Molecular Physiology.
322(1):L84-L101
[DOI] 10.1152/ajplung.00037.2021.
[PMID] 34850650.
2022
Apparent Absence of BMAL1-Dependent Skeletal Muscle-Kidney Cross Talk in Mice.
Biomolecules.
12(2)
[DOI] 10.3390/biom12020261.
[PMID] 35204763.
2022
Circadian clocks of the kidney: function, mechanism, and regulation
Physiological Reviews.
102(4):1669-1701
[DOI] 10.1152/physrev.00045.2021.
[PMID] 35575250.
2022
Circadian rhythms and renal pathophysiology
Journal of Clinical Investigation.
132(3)
[DOI] 10.1172/jci148277.
2022
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression
American Journal of Physiology-Renal Physiology.
322(4):F449-F459
[DOI] 10.1152/ajprenal.00385.2021.
[PMID] 35129370.
2022
Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.
Hypertension (Dallas, Tex. : 1979).
79(11):101161HYPERTENSIONAHA12219316-2529
[DOI] 10.1161/HYPERTENSIONAHA.122.19316.
2022
Sex differences in circadian regulation of kidney function of the mouse
American Journal of Physiology-Renal Physiology.
323(6):F675-F685
[DOI] 10.1152/ajprenal.00227.2022.
2021
Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.
Comprehensive Physiology.
12(1):2769-2798
[DOI] 10.1002/cphy.c210011.
[PMID] 34964116.
2021
Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension
Hypertension.
78(5):1185-1196
[DOI] 10.1161/hypertensionaha.121.14519.
2021
Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats.
American journal of physiology. Renal physiology.
320(2):F224-F233
[DOI] 10.1152/ajprenal.00421.2020.
[PMID] 33356955.
2021
Interplay of the Circadian Clock and Endothelin System.
Physiology (Bethesda, Md.).
36(1):35-43
[DOI] 10.1152/physiol.00021.2020.
[PMID] 33325818.
2021
Likelihood-based tests for detecting circadian rhythmicity and differential circadian patterns in transcriptomic applications.
Briefings in bioinformatics.
22(6)
[DOI] 10.1093/bib/bbab224.
[PMID] 34117739.
2020
Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.
American journal of physiology. Regulatory, integrative and comparative physiology.
318(6):R1058-R1067
[DOI] 10.1152/ajpregu.00010.2020.
[PMID] 32348679.
2020
Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice.
American journal of physiology. Renal physiology.
318(6):F1463-F1477
[DOI] 10.1152/ajprenal.00014.2020.
[PMID] 32338037.
2020
EDN1-AS, A Novel Long Non-coding RNA Regulating Endothelin-1 in Human Proximal Tubule Cells.
Frontiers in physiology.
11
[DOI] 10.3389/fphys.2020.00209.
[PMID] 32231591.
2020
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
Canadian journal of physiology and pharmacology.
98(9):579-586
[DOI] 10.1139/cjpp-2019-0688.
[PMID] 32437627.
2019
Circadian Clock Genes in Diabetic Kidney Disease (DKD).
Current diabetes reports.
19(7)
[DOI] 10.1007/s11892-019-1156-z.
[PMID] 31168658.
2019
Clock gene expression is altered in veterans with sleep apnea.
Physiological genomics.
51(3):77-82
[DOI] 10.1152/physiolgenomics.00091.2018.
[PMID] 30657733.
2019
Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure.
American journal of physiology. Renal physiology.
316(5):F807-F813
[DOI] 10.1152/ajprenal.00408.2018.
[PMID] 30759025.
2019
Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology.
316(1):R50-R58
[DOI] 10.1152/ajpregu.00381.2017.
[PMID] 30427705.
2018
Circadian clock-mediated regulation of blood pressure.
Free radical biology & medicine.
119:108-114
[DOI] 10.1016/j.freeradbiomed.2017.11.024.
[PMID] 29198725.
2018
Clocking skin sodium.
American journal of physiology. Regulatory, integrative and comparative physiology.
314(4):R542-R543
[DOI] 10.1152/ajpregu.00453.2017.
[PMID] 29351424.
2018
Predicted effect of circadian clock modulation of NHE3 of a proximal tubule cell on sodium transport.
American journal of physiology. Renal physiology.
315(3):F665-F676
[DOI] 10.1152/ajprenal.00008.2018.
[PMID] 29537313.
2018
RECENT ADVANCES IN UNDERSTANDING THE CIRCADIAN CLOCK IN RENAL PHYSIOLOGY.
Current opinion in physiology.
5:38-44
[DOI] 10.1016/j.cophys.2018.06.002.
[PMID] 30714020.
2018
Renal and colonic potassium transporters in the pregnant rat.
American journal of physiology. Renal physiology.
314(2):F251-F259
[DOI] 10.1152/ajprenal.00288.2017.
[PMID] 29046297.
2018
Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.
American journal of physiology. Renal physiology.
314(6):F1138-F1144
[DOI] 10.1152/ajprenal.00546.2017.
[PMID] 29357420.
2017
Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice.
Acta physiologica (Oxford, England).
220(1):72-82
[DOI] 10.1111/apha.12804.
[PMID] 27636900.
2017
ENaC activity in the cortical collecting duct of HKα1 H+,K+-ATPase knockout mice is uncoupled from Na+ intake.
American journal of physiology. Renal physiology.
312(6):F1073-F1080
[DOI] 10.1152/ajprenal.00401.2016.
[PMID] 28179253.
2016
Aldosterone alters the chromatin structure of the murine endothelin-1 gene.
Life sciences.
159:121-126
[DOI] 10.1016/j.lfs.2016.01.019.
[PMID] 26775567.
2016
Molecular basis of circadian rhythmicity in renal physiology and pathophysiology.
Experimental physiology.
101(8):1025-9
[DOI] 10.1113/EP085781.
[PMID] 27474264.
2016
Taking into account circadian rhythm when conducting experiments on animals.
American journal of physiology. Renal physiology.
310(6):F454-5
[DOI] 10.1152/ajprenal.00549.2015.
[PMID] 26719365.
2015
An Integrated View of Potassium Homeostasis.
The New England journal of medicine.
373(1):60-72
[DOI] 10.1056/NEJMra1313341.
[PMID] 26132942.
2015
An Integrated View of Potassium Homeostasis.
The New England journal of medicine.
373(18):1787-8
[DOI] 10.1056/NEJMc1509656.
[PMID] 26510039.
2015
Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1.
American journal of physiology. Renal physiology.
309(12):F1026-34
[DOI] 10.1152/ajprenal.00220.2015.
[PMID] 26400543.
2015
The Circadian Clock in the Regulation of Renal Rhythms.
Journal of biological rhythms.
30(6):470-86
[DOI] 10.1177/0748730415610879.
[PMID] 26527094.
2015
Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells.
American journal of physiology. Renal physiology.
309(11):F933-42
[DOI] 10.1152/ajprenal.00197.2014.
[PMID] 26377793.
2014
A Role for the Circadian Clock Protein Per1 in the Regulation of Nhe3 and Sglt1 in Human Proximal Tubule Cells
The FASEB's Journal.
28(1, S)
2014
A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells.
The Journal of biological chemistry.
289(17):11791-11806
[DOI] 10.1074/jbc.M113.531095.
[PMID] 24610784.
2014
Clock genes in hypertension: novel insights from rodent models.
Blood pressure monitoring.
19(5):249-54
[DOI] 10.1097/MBP.0000000000000060.
[PMID] 25025868.
2014
Molecular origin of the kidney clock.
Kidney international.
86(5):873-4
[DOI] 10.1038/ki.2014.239.
[PMID] 25360489.
2014
Renal Potassium Handling in the Pregnant Rat
The FASEB's Journal.
28(1, S)
2014
Tick tock: time to recognize the kidney clock.
Journal of the American Society of Nephrology : JASN.
25(7):1369-71
[DOI] 10.1681/ASN.2014020199.
[PMID] 24652798.
2014
Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.
Life sciences.
118(2):255-62
[DOI] 10.1016/j.lfs.2014.03.028.
[PMID] 24721511.
2013
A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention.
American journal of physiology. Renal physiology.
305(12):F1697-704
[DOI] 10.1152/ajprenal.00472.2013.
[PMID] 24154698.
2013
Mechanism of Per1 Action in Blood Pressure Control: Role of the Circadian Repressor Cry 2
The FASEB's Journal.
27
2013
Mechanism of the circadian clock in physiology.
American journal of physiology. Regulatory, integrative and comparative physiology.
304(12):R1053-64
[DOI] 10.1152/ajpregu.00066.2013.
[PMID] 23576606.
2013
Molecular bases of circadian rhythmicity in renal physiology and pathology.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
28(10):2421-31
[DOI] 10.1093/ndt/gft319.
[PMID] 23901050.
2013
Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney.
American journal of physiology. Regulatory, integrative and comparative physiology.
305(7):R735-47
[DOI] 10.1152/ajpregu.00195.2013.
[PMID] 23824961.
2013
Role of circadian rhythms in potassium homeostasis.
Seminars in nephrology.
33(3):229-36
[DOI] 10.1016/j.semnephrol.2013.04.003.
[PMID] 23953800.
2013
Role of Per1 and the mineralocorticoid receptor in the coordinate regulation of αENaC in renal cortical collecting duct cells.
Frontiers in physiology.
4
[DOI] 10.3389/fphys.2013.00253.
[PMID] 24062694.
2012
Advances in understanding the peripheral circadian clocks.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
26(9):3602-13
[DOI] 10.1096/fj.12-203554.
[PMID] 22661008.
2012
Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cells.
Steroids.
77(5):360-6
[DOI] 10.1016/j.steroids.2011.12.011.
[PMID] 22209709.
2012
Inhibition of Alpha Enac Expression and Enac Activity Following Blockade of the Circadian Clock-Regulatory Kinases Cki Delta/Epsilon
The FASEB's Journal.
26
2012
Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.
American journal of physiology. Renal physiology.
303(7):F918-27
[DOI] 10.1152/ajprenal.00678.2011.
[PMID] 22832921.
2012
The circadian protein period 1 contributes to blood pressure control and coordinately regulates renal sodium transport genes.
Hypertension (Dallas, Tex. : 1979).
59(6):1151-6
[DOI] 10.1161/HYPERTENSIONAHA.112.190892.
[PMID] 22526258.
2011
Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases.
Journal of the American Society of Nephrology : JASN.
22(1):49-58
[DOI] 10.1681/ASN.2010030311.
[PMID] 21164026.
2011
The circadian clock in the kidney.
Journal of the American Society of Nephrology : JASN.
22(4):598-604
[DOI] 10.1681/ASN.2010080803.
[PMID] 21436284.
2010
Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct.
American journal of physiology. Renal physiology.
298(2):F408-15
[DOI] 10.1152/ajprenal.00333.2009.
[PMID] 19923411.
2010
Pharmacological profiles of the murine gastric and colonic H,K-ATPases.
Biochimica et biophysica acta.
1800(9):906-11
[DOI] 10.1016/j.bbagen.2010.05.002.
[PMID] 20594946.
2010
Regulation of αENaC expression by the circadian clock protein Period 1 in mpkCCD(c14) cells.
Biochimica et biophysica acta.
1799(9):622-9
[DOI] 10.1016/j.bbagrm.2010.09.003.
[PMID] 20868778.
2010
The renal H+-K+-ATPases: physiology, regulation, and structure.
American journal of physiology. Renal physiology.
298(1):F12-21
[DOI] 10.1152/ajprenal.90723.2008.
[PMID] 19640897.
2010
The renal H,K-ATPases.
Current opinion in nephrology and hypertension.
19(5):478-82
[DOI] 10.1097/MNH.0b013e32833ce65f.
[PMID] 20616716.
2009
Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1).
The Journal of biological chemistry.
284(44):30087-96
[DOI] 10.1074/jbc.M109.030718.
[PMID] 19638349.
2009
Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth.
Cancer research.
69(4):1536-44
[DOI] 10.1158/0008-5472.CAN-08-3718.
[PMID] 19208833.
2009
The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice.
The Journal of clinical investigation.
119(8):2423-34
[DOI] 10.1172/JCI36908.
[PMID] 19587447.
2007
Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
13(16):4740-9
[PMID] 17699851.
2007
The renal H+, K+-ATPases as therapeutic targets.
Expert opinion on therapeutic targets.
11(7):881-90
[PMID] 17614757.
2006
Characterization of the rabbit HKalpha2 gene promoter.
Biochimica et biophysica acta.
1759(10):443-50
[PMID] 17034876.
2006
Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypothalamic metastases.
Thyroid : official journal of the American Thyroid Association.
16(12):1293-302
[PMID] 17199440.
2003
Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line.
American journal of physiology. Renal physiology.
285(4):F664-73
[PMID] 12770840.
2003
Molecular modeling of the rabbit colonic (HKalpha2a) H+, K+ ATPase.
Journal of molecular modeling.
9(5):283-9
[PMID] 12884085.
Defining the age-dependent and tissue-specific circadian transcriptome in male mice
.
[DOI] 10.1101/2022.04.27.489594.
Grants
Jan 2022
ACTIVE
Contribution of the adrenal clock to renal function
Role: Other
Funding: AMER HEART ASSOCIATION
Dec 2021
– Jun 2022
Vanderbilt O'Brien Kidney Center
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER
via NATL INST OF HLTH NIDDK
Nov 2021
ACTIVE
Regulation of sodium handling by Bmal1 under dietary potassium restriction
Role: Other
Funding: AMER HEART ASSOCIATION
Sep 2021
ACTIVE
Modulation of the renal aldosterone endothelin feedback system by the clock protein PER1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2021
ACTIVE
Endothelial Circadian Clock Protein PER1 Modulates Salt-sensitive Hypertension
Role: Co-Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
May 2021
ACTIVE
ADAPT: Autonomous Delirium Monitoring and Adaptive Prevention
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2021
ACTIVE
Centrifugal regulation of olfactory function by melanin-concentrating hormone
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCD
Jul 2020
ACTIVE
The circadian clock protein BMAL and post-translational regulation of ENaC in the kidney
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Mar 2020
– Mar 2022
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation in Male and Female Mice
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jul 2019
ACTIVE
Kidney-Specific and Sex-Dependent Regulation of Blood Pressure by the Circadian Clock Protein BMAL1
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jan 2019
– Mar 2020
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation
Role: Other
Funding: AMER HEART ASSOCIATION
Jul 2018
– Jun 2020
Mechanism of Per1-Dependent Salt-Sensitive Non-Dipping Hypertension
Role: Other
Funding: AMER HEART ASSOCIATION
Sep 2017
ACTIVE
Per1 and the kidney clock in hypertension
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Apr 2017
– Mar 2022
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Dec 2016
– Nov 2019
Novel mechanism to target the endothelin axis in aging and CKD
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2016
– Jun 2018
Blood Pressure regulation by per1 and the kidney clock
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jul 2013
– Dec 2016
Role of the Kidney in Blood Pressure Regulation by the Circadian Protein Per1
Role: Principal Investigator
Funding: AMER SOC OF NEPHROLOGY
Apr 2013
– Mar 2017
Blood Pressure Regulation by the Circadian Clock Protein Per1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Education
PhD, Biochemistry and Molecular Biology
1999-2004
·
University of Florida
B.S., Biochemistry
1996-1999
·
University of California, Riverside
Contact Details
Phones:
- Business:
- (352) 273-6887
Emails:
- Business:
- michelle.gumz@medicine.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100224
GAINESVILLE FL 32610 - Business Street:
-
PO Box 100224
GAINESVILLE FL 32610