Michelle L Gumz

Michelle L Gumz, PhD

Professor

Department: Department of Physiology and Aging
Business Phone: (352) 273-6887

About Michelle L Gumz

I am a Professor in the Department of Physiology and Aging. My research group focuses on the role of the circadian clock in the kidney and how it contributes to the regulation of renal function and blood pressure control. This work includes the study of sex differences in the action of the clock proteins PER1 and BMAL1 as well as the use of hypertension models. We use rodent models to better understand the integrative physiology of the circadian clock with the ultimate goal that our findings will contribute to the development of new therapies for kidney disease and hypertension in humans. Recently, our work has expanded to include investigation of circadian clock crosstalk between the kidneys and adrenal glands and how that influences renal function, blood pressure regulation, and the physiology of the aging kidney.

Related Links:
Additional Positions:
J. Robert and Mary Cade Professor of Physiology
2021 – Current · University of Florida
Associate Director, Center for Integrative Cardiovascular and Metabolic Diseases
2018 – Current · University of Florida

Teaching Profile

Courses Taught
2013,2020
BCH6208 Advanced Metabolism: Regulation of Key Reactions in Carbohydrate and Lipid Metabolism
2015-2025
GMS6491 Journal Club in Physiology
2020
BCH6207 Advanced Metabolism: Role of Membranes in Signal Transduction and Metabolic Control
2013-2018,2020-2025
BCH6206 Advanced Metabolism
2013-2025
BCH5413 Mammalian Molecular Biology and Genetics
2013-2014,2016-2021,2020-2025,2023-2025
BCH4905 Biochemistry Senior Research
2014-2019,2021-2023
BCH6415 Advanced Molecular and Cell Biology
2018
GMS7980 Research for Doctoral Dissertation
2018,2024-2025
BMS6638C Kidney & Urinary Tract
2014-2015,2022-2025
BCH6209 Advanced Metabolism: Regulation of Key Reactions in Amino Acid and Nucleotide Metabolism
2021
VME6934 Topics in Veterinary Medical Sciences
2024
GMS6473 Fundamentals of Physiology and Functional Genomics III
2024
GMS6472 Fundamentals of Physiology and Functional Genomics II
2024
GMS6471 Fundamentals of Physiology and Functional Genomics I
Teaching Philosophy
Teaching graduate students is one of the best parts of my job. I keep the theme of “how we know what we know” in mind for all of my lectures. The graduate level is a great setting to explore this concept, moving the students beyond the fundamental building blocks they have in place from undergraduate courses toward a deeper understanding of how that information ends up in a textbook. I like to draw lecture material from the primary literature, using classic papers dating back decades as well as the most up-to-date literature. I love to go through key experiments in detail and discuss with students the important controls and consider the relevance for human health. I keep the theme of “how we know what we know” in mind in all of the teaching that I do. Exploring this theme as part of the lecture material is a great way to teach students the scientific method in the laboratory. Whether they are evaluating data from the literature, a figure in the textbook, or even their own results from the lab, having a student dissect the underlying meaning from the hypothesis, to the outcome, to the interpretation is a powerful method that eventually allows them the confidence to exercise skepticism.

Research Profile

Dr. Gumz has a long-time interest in the molecular control of renal function. The Gumz laboratory is investigating the role of the molecular circadian clock in the kidney with the long term goal of determining how the clock in the kidney contributes to the control of blood pressure as well as to overall cardiovascular health. Aldosterone is a mineralocorticoid hormone that regulates sodium balance and blood pressure. As a graduate student, Dr. Gumz was the first to identify the circadian clock gene Period 1 (Per1) as an aldosterone target. She has subsequently shown that the PER1 protein regulates transcription of alpha ENaC, the aldosterone-regulated and rate-limiting subunit of the epithelial sodium channel that plays a key role in maintaining electrolyte balance and blood pressure. New areas of study include cross talk between the kidney clock and other tissue clocks as well as sex differences in the function of PER1 and BMAL1, another critical core clock protein.

Open Researcher and Contributor ID (ORCID)

0000-0002-1342-0878

Publications

Academic Articles
2024
Circadian Clock Disruption and Growth of Kidney Cysts in Autosomal Dominant Polycystic Kidney Disease
Journal of the American Society of Nephrology. [DOI] 10.1681/asn.0000000528.
2024
Circadian clock disruption and growth of kidney cysts in autosomal dominant polycystic kidney disease.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.08.05.606676. [PMID] 39211074.
2024
Disrupted rest-activity circadian rhythms are associated with all-cause mortality in patients with chronic kidney diseases.
Chronobiology international. 41(11):1399-1410 [DOI] 10.1080/07420528.2024.2414045. [PMID] 39445647.
2024
Recent advances in understanding the kidney circadian clock mechanism
American Journal of Physiology-Renal Physiology. 326(3):F382-F393 [DOI] 10.1152/ajprenal.00214.2023. [PMID] 38174377.
2024
Sex differences in the adrenal circadian clock: A role for BMAL1 in the regulation of urinary aldosterone excretion and renal electrolyte balance in mice.
American journal of physiology. Renal physiology. [DOI] 10.1152/ajprenal.00177.2024. [PMID] 39447118.
2024
Thick Ascending Limb Specific Inactivation of Myh9 and Myh10 Myosin Motors Results in Progressive Kidney Disease and Drives Sex-specific Cellular Adaptation in the Distal Nephron and Collecting Duct
Function. [DOI] 10.1093/function/zqae048.
2024
Time, a healer and destroyer: role for the circadian clock in driving sex-specific mechanisms of hypertension.
American journal of physiology. Heart and circulatory physiology. 327(4):H866-H868 [DOI] 10.1152/ajpheart.00590.2024. [PMID] 39212767.
2023
Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior
Function. 4(2) [DOI] 10.1093/function/zqad001. [PMID] 36778748.
2023
Aldosterone: Renal Action and Physiological Effects.
Comprehensive Physiology. 13(2):4409-4491 [DOI] 10.1002/cphy.c190043. [PMID] 36994769.
2023
Circadian Disruption and the Molecular Clock in Atherosclerosis and Hypertension.
The Canadian journal of cardiology. 39(12):1757-1771 [DOI] 10.1016/j.cjca.2023.06.416. [PMID] 37355229.
2023
Defining the age-dependent and tissue-specific circadian transcriptome in male mice.
Cell reports. 42(1) [DOI] 10.1016/j.celrep.2022.111982. [PMID] 36640301.
2023
Involvement of lysyl oxidase in the pathogenesis of arterial stiffness in chronic kidney disease
American Journal of Physiology-Renal Physiology. 324(4):F364-F373 [DOI] 10.1152/ajprenal.00239.2022. [PMID] 36825626.
2023
Male kidney-specific BMAL1 knockout mice are protected from K+-deficient, high-salt diet-induced blood pressure increases
American Journal of Physiology-Renal Physiology. 325(5):F656-F668 [DOI] 10.1152/ajprenal.00126.2023. [PMID] 37706232.
2023
Renal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm
American Journal of Physiology-Renal Physiology. 325(5):F629-F637 [DOI] 10.1152/ajprenal.00211.2023. [PMID] 37676758.
2023
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.
Canadian journal of physiology and pharmacology. 101(3):136-146 [DOI] 10.1139/cjpp-2022-0134. [PMID] 36450128.
2023
Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension – 2021 NHLBI Workshop Report
Hypertension. 80(3):503-522 [DOI] 10.1161/hypertensionaha.122.19372.
2022
A wrinkle in time: circadian biology in pulmonary vascular health and disease
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322(1):L84-L101 [DOI] 10.1152/ajplung.00037.2021. [PMID] 34850650.
2022
Apparent Absence of BMAL1-Dependent Skeletal Muscle-Kidney Cross Talk in Mice.
Biomolecules. 12(2) [DOI] 10.3390/biom12020261. [PMID] 35204763.
2022
Circadian clocks of the kidney: function, mechanism, and regulation
Physiological Reviews. 102(4):1669-1701 [DOI] 10.1152/physrev.00045.2021. [PMID] 35575250.
2022
Circadian rhythms and renal pathophysiology
Journal of Clinical Investigation. 132(3) [DOI] 10.1172/jci148277.
2022
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression
American Journal of Physiology-Renal Physiology. 322(4):F449-F459 [DOI] 10.1152/ajprenal.00385.2021. [PMID] 35129370.
2022
Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.
Hypertension (Dallas, Tex. : 1979). 79(11):101161HYPERTENSIONAHA12219316-2529 [DOI] 10.1161/HYPERTENSIONAHA.122.19316.
2022
Sex differences in circadian regulation of kidney function of the mouse
American Journal of Physiology-Renal Physiology. 323(6):F675-F685 [DOI] 10.1152/ajprenal.00227.2022.
2022
The Seventeenth International Conference on Endothelin (ET-17).
Canadian journal of physiology and pharmacology. [DOI] 10.1139/cjpp-2022-0091. [PMID] 36169157.
2021
Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.
Comprehensive Physiology. 12(1):2769-2798 [DOI] 10.1002/cphy.c210011. [PMID] 34964116.
2021
Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension
Hypertension. 78(5):1185-1196 [DOI] 10.1161/hypertensionaha.121.14519.
2021
Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats.
American journal of physiology. Renal physiology. 320(2):F224-F233 [DOI] 10.1152/ajprenal.00421.2020. [PMID] 33356955.
2021
Interplay of the Circadian Clock and Endothelin System.
Physiology (Bethesda, Md.). 36(1):35-43 [DOI] 10.1152/physiol.00021.2020. [PMID] 33325818.
2021
Likelihood-based tests for detecting circadian rhythmicity and differential circadian patterns in transcriptomic applications.
Briefings in bioinformatics. 22(6) [DOI] 10.1093/bib/bbab224. [PMID] 34117739.
2020
Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.
American journal of physiology. Regulatory, integrative and comparative physiology. 318(6):R1058-R1067 [DOI] 10.1152/ajpregu.00010.2020. [PMID] 32348679.
2020
Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice.
American journal of physiology. Renal physiology. 318(6):F1463-F1477 [DOI] 10.1152/ajprenal.00014.2020. [PMID] 32338037.
2020
EDN1-AS, A Novel Long Non-coding RNA Regulating Endothelin-1 in Human Proximal Tubule Cells.
Frontiers in physiology. 11 [DOI] 10.3389/fphys.2020.00209. [PMID] 32231591.
2020
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
Canadian journal of physiology and pharmacology. 98(9):579-586 [DOI] 10.1139/cjpp-2019-0688. [PMID] 32437627.
2019
Circadian Clock Genes in Diabetic Kidney Disease (DKD).
Current diabetes reports. 19(7) [DOI] 10.1007/s11892-019-1156-z. [PMID] 31168658.
2019
Clock gene expression is altered in veterans with sleep apnea.
Physiological genomics. 51(3):77-82 [DOI] 10.1152/physiolgenomics.00091.2018. [PMID] 30657733.
2019
Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure.
American journal of physiology. Renal physiology. 316(5):F807-F813 [DOI] 10.1152/ajprenal.00408.2018. [PMID] 30759025.
2019
Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology. 316(1):R50-R58 [DOI] 10.1152/ajpregu.00381.2017. [PMID] 30427705.
2018
Circadian clock-mediated regulation of blood pressure.
Free radical biology & medicine. 119:108-114 [DOI] 10.1016/j.freeradbiomed.2017.11.024. [PMID] 29198725.
2018
Clocking skin sodium.
American journal of physiology. Regulatory, integrative and comparative physiology. 314(4):R542-R543 [DOI] 10.1152/ajpregu.00453.2017. [PMID] 29351424.
2018
Predicted effect of circadian clock modulation of NHE3 of a proximal tubule cell on sodium transport.
American journal of physiology. Renal physiology. 315(3):F665-F676 [DOI] 10.1152/ajprenal.00008.2018. [PMID] 29537313.
2018
RECENT ADVANCES IN UNDERSTANDING THE CIRCADIAN CLOCK IN RENAL PHYSIOLOGY.
Current opinion in physiology. 5:38-44 [DOI] 10.1016/j.cophys.2018.06.002. [PMID] 30714020.
2018
Renal and colonic potassium transporters in the pregnant rat.
American journal of physiology. Renal physiology. 314(2):F251-F259 [DOI] 10.1152/ajprenal.00288.2017. [PMID] 29046297.
2018
Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.
American journal of physiology. Renal physiology. 314(6):F1138-F1144 [DOI] 10.1152/ajprenal.00546.2017. [PMID] 29357420.
2017
Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice.
Acta physiologica (Oxford, England). 220(1):72-82 [DOI] 10.1111/apha.12804. [PMID] 27636900.
2017
ENaC activity in the cortical collecting duct of HKα1 H+,K+-ATPase knockout mice is uncoupled from Na+ intake.
American journal of physiology. Renal physiology. 312(6):F1073-F1080 [DOI] 10.1152/ajprenal.00401.2016. [PMID] 28179253.
2016
Aldosterone alters the chromatin structure of the murine endothelin-1 gene.
Life sciences. 159:121-126 [DOI] 10.1016/j.lfs.2016.01.019. [PMID] 26775567.
2016
How to Find More Hours in the Day.
The Physiologist. 59(3):127-9 [PMID] 27266014.
2016
Molecular basis of circadian rhythmicity in renal physiology and pathophysiology.
Experimental physiology. 101(8):1025-9 [DOI] 10.1113/EP085781. [PMID] 27474264.
2016
Taking into account circadian rhythm when conducting experiments on animals.
American journal of physiology. Renal physiology. 310(6):F454-5 [DOI] 10.1152/ajprenal.00549.2015. [PMID] 26719365.
2015
An Integrated View of Potassium Homeostasis.
The New England journal of medicine. 373(1):60-72 [DOI] 10.1056/NEJMra1313341. [PMID] 26132942.
2015
An Integrated View of Potassium Homeostasis.
The New England journal of medicine. 373(18):1787-8 [DOI] 10.1056/NEJMc1509656. [PMID] 26510039.
2015
Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1.
American journal of physiology. Renal physiology. 309(12):F1026-34 [DOI] 10.1152/ajprenal.00220.2015. [PMID] 26400543.
2015
The Circadian Clock in the Regulation of Renal Rhythms.
Journal of biological rhythms. 30(6):470-86 [DOI] 10.1177/0748730415610879. [PMID] 26527094.
2015
Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells.
American journal of physiology. Renal physiology. 309(11):F933-42 [DOI] 10.1152/ajprenal.00197.2014. [PMID] 26377793.
2014
A Role for the Circadian Clock Protein Per1 in the Regulation of Nhe3 and Sglt1 in Human Proximal Tubule Cells
The FASEB's Journal. 28(1, S)
2014
A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells.
The Journal of biological chemistry. 289(17):11791-11806 [DOI] 10.1074/jbc.M113.531095. [PMID] 24610784.
2014
Clock genes in hypertension: novel insights from rodent models.
Blood pressure monitoring. 19(5):249-54 [DOI] 10.1097/MBP.0000000000000060. [PMID] 25025868.
2014
Molecular origin of the kidney clock.
Kidney international. 86(5):873-4 [DOI] 10.1038/ki.2014.239. [PMID] 25360489.
2014
Renal Potassium Handling in the Pregnant Rat
The FASEB's Journal. 28(1, S)
2014
Tick tock: time to recognize the kidney clock.
Journal of the American Society of Nephrology : JASN. 25(7):1369-71 [DOI] 10.1681/ASN.2014020199. [PMID] 24652798.
2014
Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.
Life sciences. 118(2):255-62 [DOI] 10.1016/j.lfs.2014.03.028. [PMID] 24721511.
2013
A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention.
American journal of physiology. Renal physiology. 305(12):F1697-704 [DOI] 10.1152/ajprenal.00472.2013. [PMID] 24154698.
2013
Mechanism of Per1 Action in Blood Pressure Control: Role of the Circadian Repressor Cry 2
The FASEB's Journal. 27
2013
Mechanism of the circadian clock in physiology.
American journal of physiology. Regulatory, integrative and comparative physiology. 304(12):R1053-64 [DOI] 10.1152/ajpregu.00066.2013. [PMID] 23576606.
2013
Molecular bases of circadian rhythmicity in renal physiology and pathology.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 28(10):2421-31 [DOI] 10.1093/ndt/gft319. [PMID] 23901050.
2013
Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney.
American journal of physiology. Regulatory, integrative and comparative physiology. 305(7):R735-47 [DOI] 10.1152/ajpregu.00195.2013. [PMID] 23824961.
2013
Role of circadian rhythms in potassium homeostasis.
Seminars in nephrology. 33(3):229-36 [DOI] 10.1016/j.semnephrol.2013.04.003. [PMID] 23953800.
2013
Role of Per1 and the mineralocorticoid receptor in the coordinate regulation of αENaC in renal cortical collecting duct cells.
Frontiers in physiology. 4 [DOI] 10.3389/fphys.2013.00253. [PMID] 24062694.
2012
Advances in understanding the peripheral circadian clocks.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(9):3602-13 [DOI] 10.1096/fj.12-203554. [PMID] 22661008.
2012
Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cells.
Steroids. 77(5):360-6 [DOI] 10.1016/j.steroids.2011.12.011. [PMID] 22209709.
2012
Inhibition of Alpha Enac Expression and Enac Activity Following Blockade of the Circadian Clock-Regulatory Kinases Cki Delta/Epsilon
The FASEB's Journal. 26
2012
Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.
American journal of physiology. Renal physiology. 303(7):F918-27 [DOI] 10.1152/ajprenal.00678.2011. [PMID] 22832921.
2012
The circadian protein period 1 contributes to blood pressure control and coordinately regulates renal sodium transport genes.
Hypertension (Dallas, Tex. : 1979). 59(6):1151-6 [DOI] 10.1161/HYPERTENSIONAHA.112.190892. [PMID] 22526258.
2011
Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases.
Journal of the American Society of Nephrology : JASN. 22(1):49-58 [DOI] 10.1681/ASN.2010030311. [PMID] 21164026.
2011
The circadian clock in the kidney.
Journal of the American Society of Nephrology : JASN. 22(4):598-604 [DOI] 10.1681/ASN.2010080803. [PMID] 21436284.
2010
Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct.
American journal of physiology. Renal physiology. 298(2):F408-15 [DOI] 10.1152/ajprenal.00333.2009. [PMID] 19923411.
2010
Pharmacological profiles of the murine gastric and colonic H,K-ATPases.
Biochimica et biophysica acta. 1800(9):906-11 [DOI] 10.1016/j.bbagen.2010.05.002. [PMID] 20594946.
2010
Regulation of αENaC expression by the circadian clock protein Period 1 in mpkCCD(c14) cells.
Biochimica et biophysica acta. 1799(9):622-9 [DOI] 10.1016/j.bbagrm.2010.09.003. [PMID] 20868778.
2010
The renal H+-K+-ATPases: physiology, regulation, and structure.
American journal of physiology. Renal physiology. 298(1):F12-21 [DOI] 10.1152/ajprenal.90723.2008. [PMID] 19640897.
2010
The renal H,K-ATPases.
Current opinion in nephrology and hypertension. 19(5):478-82 [DOI] 10.1097/MNH.0b013e32833ce65f. [PMID] 20616716.
2009
Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1).
The Journal of biological chemistry. 284(44):30087-96 [DOI] 10.1074/jbc.M109.030718. [PMID] 19638349.
2009
Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth.
Cancer research. 69(4):1536-44 [DOI] 10.1158/0008-5472.CAN-08-3718. [PMID] 19208833.
2009
The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice.
The Journal of clinical investigation. 119(8):2423-34 [DOI] 10.1172/JCI36908. [PMID] 19587447.
2007
Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research. 13(16):4740-9 [PMID] 17699851.
2007
The renal H+, K+-ATPases as therapeutic targets.
Expert opinion on therapeutic targets. 11(7):881-90 [PMID] 17614757.
2006
Characterization of the rabbit HKalpha2 gene promoter.
Biochimica et biophysica acta. 1759(10):443-50 [PMID] 17034876.
2006
Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypothalamic metastases.
Thyroid : official journal of the American Thyroid Association. 16(12):1293-302 [PMID] 17199440.
2003
Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line.
American journal of physiology. Renal physiology. 285(4):F664-73 [PMID] 12770840.
2003
Molecular modeling of the rabbit colonic (HKalpha2a) H+, K+ ATPase.
Journal of molecular modeling. 9(5):283-9 [PMID] 12884085.
Presentations
2016-04-26
Research Landscapes
Regional / Other. Continuing Education. https://youtu.be/yTING3SAn18

Grants

Sep 2024 ACTIVE
Investigating Sex Differences in the Circadian Clock Mechanism
Role: Principal Investigator
Funding: AMER PHYSIOLOGICAL SOC
Apr 2024 ACTIVE
Circadian-Coupled Neuroinflammation in Chronic Kidney Disease-Induced Arterial Stiffness
Role: Other
Funding: AMER HEART ASSOCIATION
Feb 2024 ACTIVE
Renal Circadian Clock Protein Regulation of Immune Activation
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jul 2023 ACTIVE
Renal Circadian Clock Protein Regulation of the Immune Response in Aging
Role: Other
Funding: AMER HEART ASSOCIATION
Mar 2023 ACTIVE
Sex differences in the kidney circadian clock mechanism
Role: Principal Investigator
Funding: AUGUSTA UNIVERSITY via NATL INST OF HLTH NIDDK
Jan 2023 ACTIVE
The Role of Circadian Rhythm Disruption in Polycystic Kidney Disease Progression
Role: Principal Investigator
Funding: UNIV OF KANSAS MEDICAL CTR RESEARCH INST via US ARMY MED RES ACQUISITION
Jan 2022 – Dec 2023
Contribution of the adrenal clock to renal function
Role: Other
Funding: AMER HEART ASSOCIATION
Dec 2021 – Jun 2022
Vanderbilt O'Brien Kidney Center
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER via NATL INST OF HLTH NIDDK
Nov 2021 – Oct 2023
Regulation of sodium handling by Bmal1 under dietary potassium restriction
Role: Other
Funding: AMER HEART ASSOCIATION
Sep 2021 – Aug 2023
Modulation of the renal aldosterone endothelin feedback system by the clock protein PER1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2021 – Apr 2024
Endothelial Circadian Clock Protein PER1 Modulates Salt-sensitive Hypertension
Role: Principal Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
May 2021 ACTIVE
ADAPT: Autonomous Delirium Monitoring and Adaptive Prevention
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2021 ACTIVE
Centrifugal regulation of olfactory function by melanin-concentrating hormone
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCD
Jul 2020 ACTIVE
The circadian clock protein BMAL and post-translational regulation of ENaC in the kidney
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Mar 2020 – Mar 2022
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation in Male and Female Mice
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jul 2019 ACTIVE
Kidney-Specific and Sex-Dependent Regulation of Blood Pressure by the Circadian Clock Protein BMAL1
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jan 2019 – Mar 2020
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation
Role: Other
Funding: AMER HEART ASSOCIATION
Jul 2018 – Jun 2020
Mechanism of Per1-Dependent Salt-Sensitive Non-Dipping Hypertension
Role: Other
Funding: AMER HEART ASSOCIATION
Sep 2017 – May 2024
Per1 and the kidney clock in hypertension
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Apr 2017 – Mar 2022
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Dec 2016 – Nov 2019
Novel mechanism to target the endothelin axis in aging and CKD
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2016 – Jun 2018
Blood Pressure regulation by per1 and the kidney clock
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jul 2013 – Dec 2016
Role of the Kidney in Blood Pressure Regulation by the Circadian Protein Per1
Role: Principal Investigator
Funding: AMER SOC OF NEPHROLOGY
Apr 2013 – Mar 2017
Blood Pressure Regulation by the Circadian Clock Protein Per1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK

Education

PhD, Biochemistry and Molecular Biology
1999-2004 · University of Florida
B.S., Biochemistry
1996-1999 · University of California, Riverside

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