Dr. Wingo and Dr. Gumz recently had a paper published in Hypertension. This study shows that mice lacking the circadian clock protein Per1 have significantly lower blood pressure than wild type mice and that Per1 represses the expression of ET-1, a known regulator of renal sodium reabsorption and blood pressure. These results suggest that loss of Per1 may be protective against hypertension. The goal of future studies will be to determine the mechanism by which Per1 and the circadian clock regulate blood pressure.
To read more, please visit the Hypertension website.